NBEAL2

Across TCGA patient cohorts, NBEAL2 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBEAL2-associated genes across cancer lineages are Annexin-1, c-Kit, and PCNA. Each is linked with NBEAL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NBEAL2-to-partner and partner-to-NBEAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by NBEAL2-low versus NBEAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEAL2→partner) and Y-score (partner→NBEAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.621	+2.938	<.001	<.001	3	3
SKCM	c-Kit →	-0.671	-2.700	.022	.006	3	3
UCEC	PCNA →	+0.210	+1.540	<.001	.001	3	3
COAD	Rad50 →	-0.274	-2.459	.001	.017	3	3
CESC	Bad_pS112 →	-0.281	-2.999	.004	.031	3	2
STAD	eIF4G →	+0.468	+2.459	.039	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Annexin-1 by NBEAL2 expression — UCEC

Explore this box plot interactively →