NBEAL1

Across TCGA pan-cancer cohorts, NBEAL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NBEAL1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NBEAL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NBEAL1 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where NBEAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.930	.033	30	view →
HNSC	DFS	Tertile	IV	0.962	0.778	.030	7	view →
LSCC	OS	Quartile	All	0.743	0.952	.047	3	view →
GBM	DFS	Tertile	All	0.642	0.806	.037	2	view →
UCEC	DFS	Quartile	All	0.966	0.824	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NBEAL1–COAD (DFS)

Open the COAD breakdown →