NBEAL1

Across TCGA patient cohorts, NBEAL1 mutation is significantly associated with the RNA expression of many other genes, with 6,761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBEAL1-associated genes across cancer lineages are IFNG, CXCL9, and CXCL13. Each is linked with NBEAL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NBEAL1-to-partner and partner-to-NBEAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by NBEAL1-low versus NBEAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEAL1→partner) and Y-score (partner→NBEAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFNG →	+0.639	+1.917	<.001	<.001	3	5
UCEC	CXCL9 →	+1.719	+2.032	<.001	<.001	3	5
UCEC	CXCL13 →	+1.538	+1.874	<.001	<.001	3	4
UCEC	C1QB →	+0.655	+1.364	.001	.003	3	4
UCEC	GZMH →	+0.718	+1.895	<.001	<.001	3	4
UCEC	COX7A2 →	+0.299	+1.879	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,761 associations by consensus.

IFNG by NBEAL1 expression — UCEC

Explore this box plot interactively →