NBEAL1

Across TCGA patient cohorts, NBEAL1 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBEAL1-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and Src. Each is linked with NBEAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NBEAL1-to-partner and partner-to-NBEAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NBEAL1-low versus NBEAL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEAL1→partner) and Y-score (partner→NBEAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PDCD4 →	-0.740	-3.134	.002	.017	3	3
COAD	Caspase-7-cleavedD198 →	+2.158	+3.815	<.001	<.001	3	3
COAD	Src →	-0.223	-3.157	.004	.018	3	3
COAD	ASNS →	+0.762	+3.815	<.001	<.001	3	3
COAD	c-Myc →	-0.247	-3.000	.009	.034	3	3
UCEC	ACC1 →	+0.217	+1.047	.025	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

PDCD4 by NBEAL1 expression — CESC

Explore this box plot interactively →