NBEAL1

Across TCGA cell cohorts, NBEAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,585 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NBEAL1-associated GO terms across cancer lineages are mRNA destabilization, RNA destabilization, and Positive regulation of mRNA catabolic process. Each is linked with NBEAL1 in more than 11 cancer types. Because this analysis shows association rather than direction, both NBEAL1-to-partner and partner-to-NBEAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA destabilization grouped by NBEAL1-low versus NBEAL1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEAL1→partner) and Y-score (partner→NBEAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	mRNA destabilization →	+0.056	+0.512	.002	.003	2	12
PANCREAS	RNA destabilization →	+0.052	+0.478	.004	.007	3	10
PANCREAS	Positive regulation of mRNA catabolic process →	+0.052	+0.490	<.001	.003	3	10
STOMACH	Positive regulation of mRNA metabolic process →	+0.052	+0.432	.001	.006	3	10
OESOPHAGUS	Negative regulation of hematopoietic stem cell differentiation →	+0.149	+0.566	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.052	+0.889	.002	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,585 associations by consensus.

mRNA destabilization by NBEAL1 expression — PANCREAS

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