NBEAL1

Across TCGA cell cohorts, NBEAL1 mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NBEAL1-associated genes across cancer lineages are MAPK8, CILK1, and TTC33. Each is linked with NBEAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NBEAL1-to-partner and partner-to-NBEAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK8 grouped by NBEAL1-low versus NBEAL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEAL1→partner) and Y-score (partner→NBEAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAPK8 →	+0.597	+3.212	.004	.006	2	3
LARGE_INTESTINE	CILK1 →	+0.694	+3.321	<.001	.002	3	2
LARGE_INTESTINE	TTC33 →	+0.552	+2.130	.001	<.001	3	2
LARGE_INTESTINE	PANK3 →	+0.577	+3.629	<.001	<.001	3	2
LARGE_INTESTINE	PPIL4 →	+0.435	+2.130	.004	<.001	3	2
LARGE_INTESTINE	GCH1 →	+0.518	+3.087	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

MAPK8 by NBEAL1 expression — SKIN

Explore this box plot interactively →