NBAS

Across TCGA pan-cancer cohorts, NBAS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NBAS data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NBAS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NBAS expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

LSCC, HNSC, and COAD are the cancer types where NBAS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.606	1.000	.011	17	view →
HNSC	DFS	Median	IV	0.873	0.664	.012	14	view →
COAD	DFS	Median	II,III,IV	1.000	0.885	.026	12	view →
CCRCC	DFS	Quartile	All	0.785	0.494	.009	8	view →
PDAC	OS	Quartile	III,IV	1.000	0.547	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NBAS–LSCC (DFS)

Open the LSCC breakdown →