NBAS

Across TCGA cell cohorts, NBAS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,537 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NBAS-associated GO terms across cancer lineages are Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Golgi vesicle transport, and Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Each is linked with NBAS in more than 8 cancer types. Because this analysis shows association rather than direction, both NBAS-to-partner and partner-to-NBAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by NBAS-low versus NBAS-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NBAS→partner) and Y-score (partner→NBAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.084	+0.708	<.001	<.001	3	9
OESOPHAGUS	Golgi vesicle transport →	+0.083	+0.586	.002	.002	3	8
LARGE_INTESTINE	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	+0.070	+0.594	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Intraciliary anterograde transport →	+0.090	+0.640	<.001	<.001	3	8
OESOPHAGUS	Glycoprotein biosynthetic process →	+0.036	+0.529	.001	<.001	3	8
SOFT_TISSUE	Regulation of kinetochore assembly →	+0.086	+0.620	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,537 associations by consensus.

Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by NBAS expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →