NBAS

Across TCGA cell cohorts, NBAS mutation is significantly associated with the RNA expression of many other genes, with 410 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NBAS-associated genes across cancer lineages are SMIM34A, CUEDC2, and TMEM9. Each is linked with NBAS in more than 1 cancer types. Because this analysis shows association rather than direction, both NBAS-to-partner and partner-to-NBAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM34A grouped by NBAS-low versus NBAS-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBAS→partner) and Y-score (partner→NBAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SMIM34A →	+0.035	+3.662	<.001	.005	3	2
LARGE_INTESTINE	CUEDC2 →	+0.558	+1.891	<.001	<.001	3	2
LARGE_INTESTINE	TMEM9 →	+0.474	+1.545	.006	.004	3	2
LARGE_INTESTINE	GPR108 →	+0.424	+1.891	<.001	<.001	3	2
LARGE_INTESTINE	ELP3 →	+0.473	+1.545	.005	.004	3	2
LARGE_INTESTINE	SCD5 →	+1.034	+2.584	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 410 associations by consensus.

SMIM34A by NBAS expression — BLOOD_Myeloma

Explore this box plot interactively →