NAV3

Across TCGA patient cohorts, NAV3 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAV3-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and ASNS. Each is linked with NAV3 in more than 4 cancer types. Because this analysis shows association rather than direction, both NAV3-to-partner and partner-to-NAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NAV3-low versus NAV3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAV3→partner) and Y-score (partner→NAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.750	+1.395	.001	.049	3	5
CESC	FoxM1 →	+0.207	+2.035	.018	.048	3	4
LUAD	ASNS →	+0.425	+1.874	<.001	.001	3	4
LUAD	Cyclin-B1 →	+0.465	+1.447	<.001	.001	3	4
SKCM	GAPDH →	+0.487	+2.502	.007	.001	3	4
CESC	p27 →	-0.149	-1.906	.046	.012	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Caspase-7-cleavedD198 by NAV3 expression — COAD

Explore this box plot interactively →