NAV3

Across TCGA cell cohorts, NAV3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,368 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NAV3-associated GO terms across cancer lineages are Protein depolymerization, Positive regulation of focal adhesion assembly, and Positive regulation of cell-substrate junction organization. Each is linked with NAV3 in more than 14 cancer types. Because this analysis shows association rather than direction, both NAV3-to-partner and partner-to-NAV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by NAV3-low versus NAV3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAV3→partner) and Y-score (partner→NAV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein depolymerization →	+0.123	+1.100	<.001	<.001	3	15
BONE	Positive regulation of focal adhesion assembly →	+0.178	+2.095	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.187	+2.605	.001	<.001	3	15
URINARY_TRACT	Actin filament depolymerization →	+0.203	+2.853	<.001	<.001	3	13
OVARY	PML body organization →	+0.173	+1.620	.002	.003	3	13
BONE	Actin filament severing →	+0.156	+1.941	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,368 associations by consensus.

Protein depolymerization by NAV3 expression — UPPER_AERODIGESTIVE_TRACT

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