NAV2

Across TCGA patient cohorts, NAV2 mutation is significantly associated with the RNA expression of many other genes, with 6,614 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAV2-associated genes across cancer lineages are PBK, COX11, and CETN3. Each is linked with NAV2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NAV2-to-partner and partner-to-NAV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by NAV2-low versus NAV2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAV2→partner) and Y-score (partner→NAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PBK →	+0.991	+3.182	.003	.009	3	5
SKCM	COX11 →	+0.457	+1.719	.001	.005	3	5
BLCA	CETN3 →	+0.430	+3.336	.005	.004	3	5
UCEC	PDHX →	+0.359	+1.437	<.001	<.001	3	5
UCEC	TMEM41B →	+0.219	+1.168	.005	.007	3	5
HNSC	NANS →	+0.432	+3.339	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,614 associations by consensus.

PBK by NAV2 expression — STAD

Explore this box plot interactively →