NAV2

Across TCGA patient cohorts, NAV2 mutation is significantly associated with the total protein of many other genes, with 103 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NAV2-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and 14-3-3_beta. Each is linked with NAV2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NAV2-to-partner and partner-to-NAV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NAV2-low versus NAV2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAV2→partner) and Y-score (partner→NAV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.925	+2.584	<.001	<.001	3	5
UCEC	ATM →	-0.413	-1.986	<.001	<.001	3	5
COAD	14-3-3_beta →	-0.153	-1.489	.014	.014	3	4
COAD	ASNS →	+0.420	+2.000	<.001	.027	3	4
UCEC	MSH2 →	-0.215	-2.120	<.001	<.001	3	4
COAD	EGFR_pY1068 →	-0.278	-2.115	.005	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

Caspase-7-cleavedD198 by NAV2 expression — COAD

Explore this box plot interactively →