NAV1

Across TCGA patient cohorts, NAV1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAV1-associated genes across cancer lineages are Caspase-7-cleavedD198, ACC1, and JNK2. Each is linked with NAV1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NAV1-to-partner and partner-to-NAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NAV1-low versus NAV1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAV1→partner) and Y-score (partner→NAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.954	+3.169	.001	.017	3	3
SKCM	ACC1 →	+0.389	+3.321	.015	.010	3	3
UCEC	JNK2 →	+0.222	+1.440	<.001	<.001	3	3
UCEC	ASNS →	+0.333	+1.536	<.001	.001	3	3
LUSC	HER2_pY1248 →	+0.268	+3.331	.031	.005	3	2
STAD	eIF4E →	+0.186	+2.000	.011	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Caspase-7-cleavedD198 by NAV1 expression — STAD

Explore this box plot interactively →