Across TCGA pan-cancer cohorts, NAT8B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NAT8B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NAT8B RNA is repressed in tumor relative to normal tissue. In most cancer types NAT8B is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.
KIRP, COAD, and KICH are the cancer types where NAT8B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAT8B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.