NAT8

Across TCGA patient cohorts, NAT8 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT8-associated genes across cancer lineages are Th2 cells, Macrophages, and pDC. Each is linked with NAT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT8-to-partner and partner-to-NAT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by NAT8-low versus NAT8-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT8→partner) and Y-score (partner→NAT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Th2 cells →	+0.154	+3.977	<.001	.034	3	2
UCEC	Macrophages →	+0.014	+2.165	.040	.007	3	1
UCEC	pDC →	+0.087	+3.329	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Th2 cells by NAT8 expression — LGG

Explore this box plot interactively →