NAT2

Across TCGA patient cohorts, NAT2 mutation is significantly associated with the RNA expression of many other genes, with 2,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT2-associated genes across cancer lineages are WDR7-OT1, RNU4-80P, and ZFYVE19. Each is linked with NAT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NAT2-to-partner and partner-to-NAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR7-OT1 grouped by NAT2-low versus NAT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT2→partner) and Y-score (partner→NAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WDR7-OT1 →	+0.256	+5.693	<.001	.003	3	3
LGG	RNU4-80P →	+0.275	+4.987	<.001	.009	3	2
UCEC	ZFYVE19 →	+0.513	+3.480	<.001	.002	3	2
UCEC	GOLGA2 →	+0.527	+3.748	<.001	<.001	3	2
SKCM	ARF4 →	+0.641	+3.635	<.001	.001	3	2
SKCM	GMPPB →	+0.443	+2.642	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,206 associations by consensus.

WDR7-OT1 by NAT2 expression — COAD

Explore this box plot interactively →