NAT2

Across TCGA patient cohorts, NAT2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT2-associated genes across cancer lineages are SETD2, Caveolin-1, and EGFR_pY1068. Each is linked with NAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT2-to-partner and partner-to-NAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETD2 grouped by NAT2-low versus NAT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT2→partner) and Y-score (partner→NAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SETD2 →	-0.127	-2.983	.035	.034	3	1
SKCM	Caveolin-1 →	-0.526	-3.169	.044	.018	2	2
UCEC	EGFR_pY1068 →	-0.319	-3.584	.008	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-3.000	.022	.036	3	1
UCEC	Ku80 →	+0.243	+2.472	.033	.011	3	1
UCEC	Notch1 →	+0.268	+3.183	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

SETD2 by NAT2 expression — SKCM

Explore this box plot interactively →