NAT2

Across TCGA cell cohorts, NAT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,379 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAT2-associated GO terms across cancer lineages are Cholesterol catabolic process, Sterol catabolic process, and UDP-galactose transmembrane transport. Each is linked with NAT2 in more than 5 cancer types. Because this analysis shows association rather than direction, both NAT2-to-partner and partner-to-NAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cholesterol catabolic process grouped by NAT2-low versus NAT2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT2→partner) and Y-score (partner→NAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cholesterol catabolic process →	-0.193	-0.195	<.001	.008	3	6
SOFT_TISSUE	Sterol catabolic process →	-0.193	-0.195	<.001	.008	3	6
LARGE_INTESTINE	UDP-galactose transmembrane transport →	+0.108	+1.029	<.001	<.001	3	6
SOFT_TISSUE	Meiotic chromosome separation →	-0.335	-0.278	.005	.005	3	5
SOFT_TISSUE	Proton transmembrane transport →	+0.046	+0.204	<.001	.005	3	5
LARGE_INTESTINE	Positive regulation of protein localization to cell surface →	+0.083	+1.877	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,379 associations by consensus.

Cholesterol catabolic process by NAT2 expression — SOFT_TISSUE

Explore this box plot interactively →