NAT10

Across TCGA pan-cancer cohorts, NAT10 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NAT10 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NAT10 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NAT10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and SKCM are the cancer types where NAT10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.617	.003	30	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	25	view →
SKCM	OS	Median	All	0.239	0.784	<.001	18	view →
COAD	DFS	Median	All	0.118	0.556	.029	6	view →
LIHC	OS	Median	II,III,IV	0.118	0.716	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NAT10–UCEC (DFS)

Open the UCEC breakdown →