NAT10

Across TCGA pan-cancer cohorts, NAT10 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NAT10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NAT10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NAT10 is over-expressed in tumor.

COAD, CCRCC, and HNSC are the cancer types where NAT10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAT10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.719	<.001	12	view →
CCRCC	Male	IV	+0.524	<.001	12	view →
HNSC	Male	IV	+0.550	<.001	11	view →
LSCC	Male	III,IV	+0.870	<.001	9	view →
LUAD	Male	III,IV	+0.569	<.001	9	view →
OV	All	All	+0.371	.001	2	view →
PDAC	Male	IV	+0.285	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NAT10–COAD

Open the COAD breakdown →