NAT10

Across TCGA patient cohorts, NAT10 mutation is significantly associated with the RNA expression of many other genes, with 4,221 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT10-associated genes across cancer lineages are MIR3912, RPL23AP7, and RNA5SP477. Each is linked with NAT10 in more than 2 cancer types. Because this analysis shows association rather than direction, both NAT10-to-partner and partner-to-NAT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3912 grouped by NAT10-low versus NAT10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT10→partner) and Y-score (partner→NAT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3912 →	+0.158	+1.744	<.001	.007	3	3
SKCM	RPL23AP7 →	+0.504	+3.019	.003	<.001	3	2
COAD	RNA5SP477 →	+0.805	+3.594	.005	.009	3	2
LUAD	MIR199B →	+0.203	+4.151	.002	.001	3	2
UCEC	RANBP9 →	+0.357	+2.792	.005	<.001	3	2
UCEC	POLE2 →	+0.523	+2.684	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,221 associations by consensus.

MIR3912 by NAT10 expression — UCEC

Explore this box plot interactively →