NAT10

Across TCGA patient cohorts, NAT10 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT10-associated genes across cancer lineages are TFRC, ATM, and Caspase-7-cleavedD198. Each is linked with NAT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT10-to-partner and partner-to-NAT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by NAT10-low versus NAT10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT10→partner) and Y-score (partner→NAT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.462	+1.807	.007	.024	3	2
UCEC	ATM →	-0.452	-2.308	.002	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.571	+3.019	.002	<.001	3	2
SKCM	ERK2 →	+0.299	+2.824	.004	.034	3	2
UCEC	14-3-3_beta →	-0.101	-1.558	.001	.032	3	1
UCEC	eIF4E →	+0.138	+2.087	.044	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

TFRC by NAT10 expression — UCEC

Explore this box plot interactively →