NAT10

Across TCGA cell cohorts, NAT10 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,334 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NAT10-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, rRNA metabolic process, and Maturation of SSU-rRNA. Each is linked with NAT10 in more than 17 cancer types. Because this analysis shows association rather than direction, both NAT10-to-partner and partner-to-NAT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by NAT10-low versus NAT10-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT10→partner) and Y-score (partner→NAT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.103	+0.807	<.001	<.001	3	18
BONE	rRNA metabolic process →	+0.132	+0.852	.003	.007	3	17
LUNG_SCLC	Maturation of SSU-rRNA →	+0.127	+0.653	<.001	<.001	3	17
BLOOD_Lymphoma	Ribosome biogenesis →	+0.090	+0.791	<.001	<.001	3	17
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.163	+0.871	<.001	<.001	3	17
BONE	rRNA processing →	+0.133	+0.892	.004	.005	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,334 associations by consensus.

Transcription initiation at RNA polymerase I promoter by NAT10 expression — BLOOD_Lymphoma

Explore this box plot interactively →