NAT10

Across TCGA cell cohorts, NAT10 mutation is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible NAT10-associated genes across cancer lineages are HTR1B, CYP7A1, and HMX3. Each is linked with NAT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT10-to-partner and partner-to-NAT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1B grouped by NAT10-low versus NAT10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT10→partner) and Y-score (partner→NAT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTR1B →	+0.050	+3.351	<.001	.002	3	2
LARGE_INTESTINE	CYP7A1 →	+0.033	+3.257	<.001	.001	3	2
LARGE_INTESTINE	HMX3 →	+0.506	+3.531	.001	.007	3	2
LUNG_SCLC	ASIC5 →	+0.105	+4.684	<.001	<.001	3	2
CNS	OR4D1 →	+0.027	+3.196	.002	.004	3	1
CNS	ASB17 →	+0.010	+4.035	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

HTR1B by NAT10 expression — LARGE_INTESTINE

Explore this box plot interactively →