NAT1

Across TCGA pan-cancer cohorts, NAT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NAT1 data layer compared with 29 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NAT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NAT1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where NAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.886	.020	12	view →
LUAD	OS	Tertile	III,IV	1.000	0.719	.007	8	view →
CCRCC	DFS	Quartile	All	0.852	0.640	.024	5	view →
GBM	OS	Tertile	All	0.292	0.566	.044	2	view →
HNSC	DFS	Median	IV	0.924	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NAT1–COAD (DFS)

Open the COAD breakdown →