NAT1

Across TCGA patient cohorts, NAT1 mutation is significantly associated with the RNA expression of many other genes, with 1,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT1-associated genes across cancer lineages are RNU6-340P, RNU6-1127P, and RNU6-1082P. Each is linked with NAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT1-to-partner and partner-to-NAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-340P grouped by NAT1-low versus NAT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT1→partner) and Y-score (partner→NAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-340P →	+0.480	+8.741	<.001	<.001	3	2
COAD	RNU6-1127P →	+0.644	+6.721	<.001	<.001	3	2
LUSC	RNU6-1082P →	+0.365	+4.365	.004	.007	3	2
UCEC	RNA5SP86 →	+0.418	+2.621	<.001	.002	3	2
UCEC	RN7SKP12 →	+0.201	+2.873	<.001	<.001	3	2
BLCA	RNU6-359P →	+0.537	+6.289	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,264 associations by consensus.

RNU6-340P by NAT1 expression — COAD

Explore this box plot interactively →