NAT1

Across TCGA patient cohorts, NAT1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAT1-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and eIF4G. Each is linked with NAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAT1-to-partner and partner-to-NAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by NAT1-low versus NAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAT1→partner) and Y-score (partner→NAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.421	+3.710	.001	<.001	3	2
UCEC	14-3-3_beta →	-0.102	-3.295	.011	.009	3	1
UCEC	eIF4G →	+0.265	+1.906	.034	.016	3	1
UCEC	Fibronectin →	-0.280	-2.797	.034	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.584	.008	.010	3	1
UCEC	JNK2 →	+0.171	+2.331	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

p62 Lck ligand by NAT1 expression — UCEC

Explore this box plot interactively →