NASP

Across TCGA pan-cancer cohorts, NASP mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NASP’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NASP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NASP is over-expressed in tumor.

CCRCC, HNSC, and COAD are the cancer types where NASP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NASP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.560	<.001	11	view →
HNSC	Male	II,III,IV	+0.506	<.001	11	view →
COAD	Male	III,IV	+0.488	<.001	11	view →
LSCC	Male	All	+1.024	<.001	9	view →
LUAD	Female	III,IV	+0.873	<.001	9	view →
PDAC	Male	All	+0.362	<.001	7	view →
OV	All	All	+0.752	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NASP–CCRCC

Open the CCRCC breakdown →