NARS2

Across TCGA patient cohorts, NARS2 mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NARS2-associated genes across cancer lineages are MIR511, LINC01831, and RNU6-706P. Each is linked with NARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NARS2-to-partner and partner-to-NARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR511 grouped by NARS2-low versus NARS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NARS2→partner) and Y-score (partner→NARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR511 →	+0.223	+5.163	<.001	.002	3	2
SKCM	LINC01831 →	+0.182	+3.744	<.001	.003	3	2
LUSC	RNU6-706P →	+0.273	+4.297	<.001	.009	3	2
LUAD	RNA5SP72 →	+0.520	+5.584	<.001	.002	3	2
LUAD	OR8X1P →	+0.116	+5.087	<.001	.004	3	2
BLCA	HLA-N →	+0.289	+3.948	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

MIR511 by NARS2 expression — SKCM

Explore this box plot interactively →