NARS2

Across TCGA cell cohorts, NARS2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NARS2-associated genes across cancer lineages are KRTAP9-4, FAM205A, and NDP. Each is linked with NARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NARS2-to-partner and partner-to-NARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-4 grouped by NARS2-low versus NARS2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NARS2→partner) and Y-score (partner→NARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP9-4 →	+0.020	+4.643	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.614	<.001	.002	3	1
BLOOD_Leukemia	NDP →	+0.050	+3.855	<.001	.007	3	1
BLOOD_Leukemia	PRRG3 →	+0.009	+4.507	<.001	.001	3	1
BLOOD_Leukemia	SLC7A14 →	+0.005	+4.060	<.001	.003	3	1
BLOOD_Leukemia	KRT6C →	+0.017	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

KRTAP9-4 by NARS2 expression — LUNG_SCLC

Explore this box plot interactively →