NARS1

Across TCGA patient cohorts, NARS1 mutation is significantly associated with the RNA expression of many other genes, with 3,397 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NARS1-associated genes across cancer lineages are RN7SL596P, CCNYL3, and PAXIP1. Each is linked with NARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NARS1-to-partner and partner-to-NARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL596P grouped by NARS1-low versus NARS1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NARS1→partner) and Y-score (partner→NARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL596P →	+0.232	+4.448	<.001	.006	3	2
BRCA	CCNYL3 →	+0.041	+6.725	<.001	<.001	3	2
UCEC	PAXIP1 →	+0.412	+2.201	.001	<.001	3	2
UCEC	TMUB1 →	+0.319	+3.016	.007	<.001	3	2
UCEC	NUDT2 →	+0.483	+2.201	.001	<.001	3	2
UCEC	CIAO2B →	+0.381	+1.895	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,397 associations by consensus.

RN7SL596P by NARS1 expression — BRCA

Explore this box plot interactively →