NARS1

Across TCGA patient cohorts, NARS1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NARS1-associated genes across cancer lineages are ATM, 4E-BP1, and 14-3-3_beta. Each is linked with NARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NARS1-to-partner and partner-to-NARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NARS1-low versus NARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NARS1→partner) and Y-score (partner→NARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.468	-2.169	.005	.003	3	2
UCEC	4E-BP1 →	+0.244	+3.169	.016	.018	3	2
UCEC	14-3-3_beta →	-0.113	-2.558	.002	.010	3	1
UCEC	A-Raf_pS299 →	-0.141	-2.115	.001	.017	3	1
UCEC	ERK2 →	+0.183	+1.765	.011	.014	3	1
UCEC	GATA6 →	-0.130	-1.407	.024	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by NARS1 expression — UCEC

Explore this box plot interactively →