NARF

Across TCGA cell cohorts, NARF mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NARF-associated genes across cancer lineages are BVES, SULT6B1, and CLEC4F. Each is linked with NARF in more than 1 cancer types. Because this analysis shows association rather than direction, both NARF-to-partner and partner-to-NARF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BVES grouped by NARF-low versus NARF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NARF→partner) and Y-score (partner→NARF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BVES →	+0.402	+3.355	.007	.007	3	1
LARGE_INTESTINE	SULT6B1 →	+0.027	+3.562	<.001	.002	3	1
LARGE_INTESTINE	CLEC4F →	+0.212	+3.974	.003	.002	3	1
LARGE_INTESTINE	GJD2 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GFRA2 →	+0.045	+3.665	<.001	.004	3	1
LARGE_INTESTINE	CPN2 →	+0.046	+4.714	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

BVES by NARF expression — LARGE_INTESTINE

Explore this box plot interactively →