NAPSB

Across TCGA patient cohorts, NAPSB mutation is significantly associated with the RNA expression of many other genes, with 282 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPSB-associated genes across cancer lineages are TRAJ20, RN7SL643P, and SAR1B. Each is linked with NAPSB in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPSB-to-partner and partner-to-NAPSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ20 grouped by NAPSB-low versus NAPSB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPSB→partner) and Y-score (partner→NAPSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TRAJ20 →	+0.433	+3.425	.002	.003	3	2
HNSC	RN7SL643P →	+0.110	+4.655	.003	.007	3	2
UCEC	SAR1B →	+0.537	+3.265	.004	.008	3	1
UCEC	CPS1 →	+0.811	+3.523	.002	.002	3	1
UCEC	MAPK9 →	+0.500	+3.201	.003	.009	3	1
UCEC	LAG3 →	+1.347	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 282 associations by consensus.

TRAJ20 by NAPSB expression — SKCM

Explore this box plot interactively →