NAPSB

Across TCGA patient cohorts, NAPSB mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPSB-associated genes across cancer lineages are Shc_pY317, SF2, and STAT5a. Each is linked with NAPSB in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPSB-to-partner and partner-to-NAPSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by NAPSB-low versus NAPSB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPSB→partner) and Y-score (partner→NAPSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.197	-3.000	.024	.037	3	1
UCEC	SF2 →	-0.124	-2.986	.049	.037	1	1
UCEC	STAT5a →	+0.581	+3.000	.011	.037	1	1
UCEC	ATM →	-0.630	-3.000	.016	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Shc_pY317 by NAPSB expression — UCEC

Explore this box plot interactively →