NAPSA

Across TCGA patient cohorts, NAPSA mutation is significantly associated with the RNA expression of many other genes, with 751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPSA-associated genes across cancer lineages are ACSL6-AS1, HMGB1P15, and RN7SL687P. Each is linked with NAPSA in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPSA-to-partner and partner-to-NAPSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSL6-AS1 grouped by NAPSA-low versus NAPSA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPSA→partner) and Y-score (partner→NAPSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ACSL6-AS1 →	+0.026	+4.289	<.001	.007	3	2
BLCA	HMGB1P15 →	+0.492	+3.892	<.001	.004	3	2
BLCA	RN7SL687P →	+0.249	+4.057	.001	.001	3	2
BLCA	RNA5SP271 →	+0.554	+4.095	<.001	.001	3	2
LUAD	FAR1P1 →	+0.115	+4.426	<.001	.006	3	2
COAD	UBL5P3 →	+0.351	+4.308	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

ACSL6-AS1 by NAPSA expression — BLCA

Explore this box plot interactively →