NAPSA

Across TCGA patient cohorts, NAPSA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPSA-associated genes across cancer lineages are Cyclin-B1, A-Raf_pS299, and ERK2. Each is linked with NAPSA in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPSA-to-partner and partner-to-NAPSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NAPSA-low versus NAPSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPSA→partner) and Y-score (partner→NAPSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.746	+3.459	.001	.005	3	2
UCEC	A-Raf_pS299 →	-0.134	-2.321	.008	.034	3	1
UCEC	ERK2 →	+0.193	+2.321	.018	.034	3	1
UCEC	FoxM1 →	+0.245	+1.700	.025	.044	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-2.575	.032	.010	3	1
UCEC	MEK1 →	+0.431	+2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Cyclin-B1 by NAPSA expression — UCEC

Explore this box plot interactively →