NAPRT

Across TCGA patient cohorts, NAPRT mutation is significantly associated with the RNA expression of many other genes, with 1,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPRT-associated genes across cancer lineages are FXYD6P3, MTND1P4, and SIGLEC27P. Each is linked with NAPRT in more than 2 cancer types. Because this analysis shows association rather than direction, both NAPRT-to-partner and partner-to-NAPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXYD6P3 grouped by NAPRT-low versus NAPRT-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPRT→partner) and Y-score (partner→NAPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FXYD6P3 →	+0.108	+4.314	<.001	.009	3	3
BLCA	MTND1P4 →	+0.180	+4.433	<.001	.007	3	3
COAD	SIGLEC27P →	+0.184	+4.807	<.001	.004	3	2
BLCA	OR6P1 →	+0.035	+5.229	.002	.002	3	2
HNSC	MIR1262 →	+0.370	+3.517	<.001	.008	3	2
HNSC	MTCO1P17 →	+0.103	+3.518	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,035 associations by consensus.

FXYD6P3 by NAPRT expression — BLCA

Explore this box plot interactively →