NAPRT

Across TCGA patient cohorts, NAPRT mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPRT-associated genes across cancer lineages are MEK1, eIF4E, and INPP4B. Each is linked with NAPRT in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPRT-to-partner and partner-to-NAPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NAPRT-low versus NAPRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPRT→partner) and Y-score (partner→NAPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.470	+3.459	.004	.005	3	2
UCEC	eIF4E →	+0.193	+2.700	.043	.006	3	1
UCEC	INPP4B →	-0.372	-3.169	.010	.018	3	1
UCEC	Ku80 →	+0.320	+2.013	.002	.018	3	1
UCEC	Mre11 →	-0.089	-2.000	.020	.032	3	1
UCEC	p62 Lck ligand →	+0.448	+3.807	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by NAPRT expression — UCEC

Explore this box plot interactively →