NAPEPLD

Across TCGA patient cohorts, NAPEPLD mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAPEPLD-associated genes across cancer lineages are GSK-3_pS9, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with NAPEPLD in more than 1 cancer types. Because this analysis shows association rather than direction, both NAPEPLD-to-partner and partner-to-NAPEPLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by NAPEPLD-low versus NAPEPLD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAPEPLD→partner) and Y-score (partner→NAPEPLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.367	-1.584	.011	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.451	-1.912	.005	.005	3	2
UCEC	PDCD4 →	-0.613	-2.990	<.001	<.001	3	2
UCEC	PKC-b-II_pS660 →	-0.338	-2.807	<.001	<.001	3	2
UCEC	TFRC →	+0.417	+1.584	.029	.019	3	2
UCEC	ASNS →	+0.465	+2.000	<.001	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GSK-3_pS9 by NAPEPLD expression — UCEC

Explore this box plot interactively →