NAPB

Across TCGA pan-cancer cohorts, NAPB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NAPB data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NAPB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NAPB expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where NAPB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.793	0.490	.002	13	view →
LUAD	DFS	Quartile	All	0.677	0.966	.001	12	view →
LSCC	OS	Median	II,III,IV	0.959	0.709	.004	9	view →
PDAC	DFS	Tertile	III,IV	0.979	0.498	.006	6	view →
UCEC	DFS	Quartile	III,IV	0.343	1.000	.027	4	view →
CCRCC	DFS	Tertile	III,IV	0.724	0.935	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NAPB–HNSC (DFS)

Open the HNSC breakdown →