NAPA

Across TCGA pan-cancer cohorts, NAPA mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NAPA data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher NAPA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NAPA expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, PDAC, and COAD are the cancer types where NAPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.971	0.755	<.001	9	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
UCEC	DFS	Median	II,III,IV	0.809	1.000	.030	6	view →
LUAD	DFS	Tertile	All	1.000	0.530	.016	6	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	2	view →
CCRCC	DFS	Quartile	All	1.000	0.836	.037	1	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NAPA–GBM (OS)

Open the GBM breakdown →