Across TCGA patient cohorts, NAP1L1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAP1L1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with NAP1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAP1L1-to-partner and partner-to-NAP1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAP1L1→partner) and Y-score (partner→NAP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.094	-3.295	.019	.009	3	1
UCEC	EGFR_pY1068 →	-0.212	-1.906	.035	.016	3	1
UCEC	eIF4E →	+0.230	+3.087	.006	<.001	3	1
UCEC	IGFBP2 →	-0.738	-2.321	.004	.033	3	1
UCEC	JNK2 →	+0.292	+2.469	<.001	.010	3	1
UCEC	Ku80 →	+0.273	+1.498	.003	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

NAP1L1 survival (RNA) · tumor vs normal (RNA) · all NAP1L1 data types