NANS

Across TCGA pan-cancer cohorts, NANS Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NANS data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher NANS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NANS expression acts as an unfavorable survival marker.

THCA, SKCM, and ESCA are the cancer types where NANS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.087	0.896	<.001	24	view →
SKCM	DFS	Median	All	0.181	0.740	<.001	8	view →
ESCA	DFS	Median	All	0.211	0.535	.027	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NANS–THCA (DFS)

Open the THCA breakdown →