NANS

Across TCGA pan-cancer cohorts, NANS mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NANS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NANS mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NANS is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where NANS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NANS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.491	<.001	11	view →
CCRCC	Male	II,III,IV	+0.297	<.001	11	view →
LUAD	Female	All	+0.443	<.001	9	view →
PDAC	Female	All	−0.474	<.001	5	view →
LSCC	All	All	+0.162	<.001	5	view →
HNSC	All	II,III,IV	−0.259	.020	4	view →
OV	All	All	+0.373	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NANS–COAD

Open the COAD breakdown →