NANS

Across TCGA patient cohorts, NANS mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NANS-associated genes across cancer lineages are SNORD116-10, RNU6-933P, and DPY19L4P2. Each is linked with NANS in more than 2 cancer types. Because this analysis shows association rather than direction, both NANS-to-partner and partner-to-NANS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-10 grouped by NANS-low versus NANS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANS→partner) and Y-score (partner→NANS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD116-10 →	+0.519	+6.624	<.001	.001	3	3
UCEC	RNU6-933P →	+0.403	+2.184	.004	.005	3	2
UCEC	DPY19L4P2 →	+0.140	+2.239	<.001	.004	3	2
UCEC	LINC01047 →	+0.126	+2.315	.001	.003	3	2
ESCA	MIR4472-1 →	+0.585	+4.564	<.001	.004	3	1
ESCA	MIR4279 →	+0.415	+4.311	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

SNORD116-10 by NANS expression — SKCM

Explore this box plot interactively →