NANS

Across TCGA patient cohorts, NANS mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NANS-associated genes across cancer lineages are ATM, GATA6, and Rab25. Each is linked with NANS in more than 1 cancer types. Because this analysis shows association rather than direction, both NANS-to-partner and partner-to-NANS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NANS-low versus NANS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NANS→partner) and Y-score (partner→NANS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.572	-3.169	.021	.020	3	1
UCEC	GATA6 →	-0.197	-3.162	.019	.019	2	1
UCEC	Rab25 →	-0.567	-3.169	.001	.019	2	1
UCEC	c-Kit →	-0.296	-3.169	.020	.020	2	1
UCEC	Annexin-1 →	+0.995	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ATM by NANS expression — UCEC

Explore this box plot interactively →