NANS

Across TCGA cell cohorts, NANS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,096 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NANS-associated GO terms across cancer lineages are GDP-mannose metabolic process, UDP-N-acetylglucosamine metabolic process, and Amino sugar biosynthetic process. Each is linked with NANS in more than 7 cancer types. Because this analysis shows association rather than direction, both NANS-to-partner and partner-to-NANS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDP-mannose metabolic process grouped by NANS-low versus NANS-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NANS→partner) and Y-score (partner→NANS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GDP-mannose metabolic process →	+0.141	+1.100	<.001	<.001	3	8
BLOOD_Myeloma	UDP-N-acetylglucosamine metabolic process →	+0.102	+0.751	.001	<.001	3	7
BLOOD_Myeloma	Amino sugar biosynthetic process →	+0.091	+0.733	<.001	<.001	3	7
BONE	COPII-coated vesicle cargo loading →	+0.113	+0.818	<.001	.001	3	7
BONE	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.105	+1.308	<.001	<.001	3	7
BONE	Regulation of monocyte chemotaxis →	+0.243	+0.998	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,096 associations by consensus.

GDP-mannose metabolic process by NANS expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →