NANP

Across TCGA pan-cancer cohorts, NANP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NANP data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NANP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NANP expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where NANP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.317	0.754	.001	20	view →
CCRCC	DFS	Median	II,III,IV	0.451	1.000	.008	11	view →
LSCC	OS	Median	All	0.890	0.699	.016	11	view →
HNSC	DFS	Median	IV	0.915	1.000	.020	4	view →
GBM	DFS	Median	All	0.299	0.436	.029	2	view →
LUAD	DFS	Tertile	All	1.000	0.853	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NANP–PDAC (OS)

Open the PDAC breakdown →